| 產品編號 |
bs-23103R-Gold |
| 英文名稱1 |
Rabbit Anti-Ki-67/Gold Conjugated antibody
|
| 中文名稱 |
膠體金標記的Ki67蛋白抗體 |
| 別 名 |
Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki-67; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_MOUSE. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul（10nm 15nm 35nm）
|
| 研究領域 |
腫瘤 細胞生物 信號轉導 轉錄調節(jié)因子 細胞類型標志物 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應 |
Human, Mouse,
|
| 產品應用 |
IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
358kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
0.4mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from mouse Ki-67 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 |
Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產品介紹 |
background:
Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.
Function:
Thought to be required for maintaining cell proliferation.
Subcellular Location:
Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.
Similarity:
Contains 1 FHA domain.
Database links:
Entrez Gene: 4288 Human
Entrez Gene: 17345 Mouse
Entrez Gene: 246042 Rat
Omim: 176741 Human
SwissProt: P46013 Human
SwissProt: Q91VE6 Mouse
SwissProt: Q5RJM0 Rat
Unigene: 689823 Human
Unigene: 80976 Human
Unigene: 4078 Mouse
Unigene: 233802 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
細胞增殖標志物(Proliferation Marker)
Ki67與PCNA一樣，為細胞增殖的一種標記，在細胞凋亡中S、G2 、M期均有表達，G0期缺如。
Ki-67增殖指數高低與許多腫瘤的分化程度、浸潤、轉移以及預后密切相關，因此被廣泛作為各種惡性腫瘤的必檢項目之一。
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