| 產(chǎn)品編號 |
bs-19787R-HRP |
| 英文名稱1 |
Rabbit Anti-phospho-NFAT4 (Ser165)/HRP Conjugated antibody
|
| 中文名稱 |
辣根過氧化物酶標記的磷酸化T細胞轉(zhuǎn)錄因子NFAT4抗體 |
| 別 名 |
NFAT4 (phospho S165); p-NFAT4 (phospho S165); C80703; cytoplasmic 3; D8Ertd281e; NF AT4; NF ATc3; NF-AT4; NF-ATc3; NFAC3_HUMAN; NFATc3; NFATx; Nuclear factor of activated T cells, cytoplasmic 3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; Nuclear factor of activated T-cells; T cell transcription factor NFAT4; T-cell transcription factor NFAT4. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 產(chǎn)品類型 |
磷酸化抗體 |
| 研究領(lǐng)域 |
細胞生物 信號轉(zhuǎn)導 自然殺傷細胞 t-淋巴細胞 表觀遺傳學 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應 |
(predicted: Human, Mouse, Chicken, Cow, Horse, Rabbit, Sheep, )
|
| 產(chǎn)品應用 |
WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
116kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthesised phosphopeptide derived from human NFAT4 around the phosphorylation site of Ser165 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
Function:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.
Subcellular Location:
Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity:
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.
Post-translational modifications:
Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin.
Similarity:
Contains 1 RHD (Rel-like) domain.
Database links:
Entrez Gene: 4775 Human
Entrez Gene: 18021 Mouse
Entrez Gene: 361400 Rat
Omim: 602698 Human
SwissProt: Q12968 Human
SwissProt: P97305 Mouse
Unigene: 436585 Human
Unigene: 383185 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
|
