| 產(chǎn)品編號(hào) |
bs-17566R-BF647 |
| 英文名稱1 |
Rabbit Anti-OTUD5/DUBA /BF647 Conjugated antibody
|
| 中文名稱 |
BF647標(biāo)記的去泛素酶A抗體 |
| 別 名 |
Deubiquinating enzyme A;
Deubiquitinating enzyme A;
DKFZp761A052;
DUBA;
MGC104871;
OTTHUMP00000025821;
OTU domain containing 5;
OTU domain containing protein 5;
OTU domain-containing protein 5;
OTUD 5;
otud5;
OTUD5_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) 泛素 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, Mouse, Rat, Chicken, Rabbit, )
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
61kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human OTUD5/DUBA |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Function:
Negative regulator of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production.
Subunit:
Interacts with TRAF3.
Tissue Specificity:
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.
Post-translational modifications:
Phosphorylation at Ser-177 is required for deubiquitinating activity.
Similarity:
Belongs to the peptidase C85 family.
Contains 1 OTU domain.
Database links:
Entrez Gene: 55593 Human
Entrez Gene: 54644 Mouse
Entrez Gene: 363452 Rat
Omim: 300713 Human
SwissProt: Q96G74 Human
SwissProt: Q3U2S4 Mouse
SwissProt: Q2YDU3 Rat
Unigene: 496098 Human
Unigene: 142827 Mouse
Unigene: 97794 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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