| 產(chǎn)品編號(hào) |
bs-4608R-RBITC |
| 英文名稱1 |
Rabbit Anti-CUEDC2/RBITC Conjugated antibody
|
| 中文名稱 |
羅丹明（RBITC）標(biāo)記的CUE結(jié)構(gòu)域蛋白2抗體 |
| 別 名 |
bA18I14.5; C10orf66; Chromosome 10 open reading frame 66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUED2_HUMAN; Cuedc2; MGC2491; OTTHUMP00000020368. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 免疫學(xué) 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo) 激酶和磷酸酶 表觀遺傳學(xué) 泛素 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
|
| 產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
32kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human CUE doma |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.
Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Subunit:
Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
DISEASE:
Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
Similarity:
Belongs to the CUEDC2 family.
Contains 1 CUE domain.
Database links:
Entrez Gene: 79004 Human
Entrez Gene: 67116 Mouse
Entrez Gene: 294009 Rat
Omim: 614142 Human
SwissProt: Q9H467 Human
SwissProt: Q9CXX9 Mouse
SwissProt: A1L131 Rat
Unigene: 500874 Human
Unigene: 218848 Mouse
Unigene: 19673 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CUEDC2(CUE Domain Containing 2)能夠結(jié)合IKKα和IKKβ,并通過使IKKα和IKKβ去磷酸化而抑制NF-κ信號(hào)通路。CUEDC2能特異性結(jié)合雌激素受體（ER），并導(dǎo)致ER的泛素化降解.抑制乳腺癌細(xì)胞的生長。
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