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Rabbit Anti-ADRB1/Cy7 Conjugated antibody (bs-0498R-Cy7)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0498R-Cy7
英文名稱(chēng)1 Rabbit Anti-ADRB1/Cy7 Conjugated antibody
中文名稱(chēng) Cy7標(biāo)記的腎上腺素能受體β1抗體
別    名 beta 1 Adrenergic Receptor; beta 1 Adrenergic Receptor; ADRB1R; Adrenergic beta 1 receptor; B1AR; Beta 1 adrenoceptor; Beta 1 adrenoreceptor; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR; ADR B1; ADRB 1; ADRB1; ADRB1_HUMAN; ADRB1R; Adrenergic beta 1 receptor; Adrenoceptor beta 1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  通道蛋白  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Pig, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADRB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Beta-adrenergic receptors (Beta-1 adrenoreceptor) mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Subcellular location cell membrane; Multi-pass membrane protein. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Belongs to the G-protein coupled receptor 1 family.

Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

Subunit:
Interacts with GOPC, MAGI3 and DLG4.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.

Post-translational modifications:
Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Adrenergic receptor subfamily. ADRB1 sub-subfamily.

Database links:

Entrez Gene: 153 Human

Entrez Gene: 11554 Mouse

Entrez Gene: 24925 Rat

Omim: 109630 Human

SwissProt: P08588 Human

SwissProt: P34971 Mouse

SwissProt: P18090 Rat

Unigene: 99913 Human

Unigene: 46797 Mouse

Unigene: 87064 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

β1腎上腺素能受體(Beta-adrenergic Receptor-1 )在接受交感神經(jīng)節(jié)后纖維支配的各種器官中存在著與腎上腺素、去甲腎上腺素起反應(yīng)的受體,稱(chēng)為腎上腺素能受體。其化學(xué)性質(zhì)尚不清楚。用對(duì)藥物反應(yīng)的方法,腎上腺素能受體可分為α及β兩個(gè)類(lèi)型。腎上腺素對(duì)α、β及D型受體均起作用,而去甲腎上腺素主要對(duì)α型起作用。
β1AR所引起的反應(yīng)為支氣管擴(kuò)張、血管擴(kuò)張等,腎上腺素受體可被β13,4-dichloroisoproterenol(D-CI)等阻斷藥物所抑制。
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