| 產(chǎn)品編號 |
bs-0015R-PE-Cy5 |
| 英文名稱1 |
Rabbit Anti-IGF II/PE-Cy5 Conjugated antibody
|
| 中文名稱 |
PE-Cy5標記的胰島素樣生長因子-II抗體 |
| 別 名 |
C11orf43; FLJ22066; FLJ44734; IGF 2; IGF II; IGF-II; IGF2; IGF2_HUMAN; IGFII; INSIGF; insulin like growth factor 2 (somatomedin A); Insulin like Growth Factor 2; Insulin like growth factor II; Insulin like growth factor II precursor; Insulin like growth factor type 2; Insulin-like Growth Factor 2; Insulin-like Growth Factor 2; pp9974; Preptin; putative insulin like growth factor II associated protein; Somatomedin A; Somatomedin A; Somatomedin-A. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
免疫學 發(fā)育生物學 信號轉(zhuǎn)導 生長因子和激素 糖尿病 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應 |
Rat,
(predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Sheep, )
|
| 產(chǎn)品應用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
7.4kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human IGF II |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The IGF2 gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is expressed only from the paternally inherited allele and is an imprinted gene which is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Insulin Like Growth Factor-2 (IGF-2) is a polypeptide growth factor, which stimulates the proliferation of a wide range of cell types.
Function:
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Subcellular Location:
Secreted.
Post-translational modifications:
O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.
DISEASE:
Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:180860]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.
Similarity:
Belongs to the insulin family.
Database links:
Entrez Gene: 3481 Human
Entrez Gene: 281240 Cow
Entrez Gene: 16002 Mouse
Entrez Gene: 24483 Rat
Omim: 147470 Human
SwissProt: P07456 Cow
SwissProt: P01344 Human
SwissProt: P09535 Mouse
SwissProt: P01346 Rat
Unigene: 272259 Human
Unigene: 718427 Human
Unigene: 3862 Mouse
Unigene: 118681 Rat
Unigene: 224460 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰島素樣生長因子2(IGF-2又稱Somatomedin A)，是一種生長調(diào)節(jié)激素，由肝分泌并入血液循環(huán)的中性多肽，具有調(diào)節(jié)生長和代謝、胰島素樣及促細胞分裂的活性，為主要的胚胎生長因子。
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