| 產(chǎn)品編號(hào) | bs-1449R-AP |
| 英文名稱1 | Rabbit Anti-Prohibitin/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的抑制素/腫瘤抑制因子抗體 |
| 別 名 | Mitochondrial Marker; PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 染色質(zhì)和核信號(hào) 細(xì)胞凋亡 細(xì)胞類型標(biāo)志物 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, Rat, (predicted: Dog, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Prohibitin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Subunit: Interacts with PHB2. Interacts with STOML2. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: Widely expressed in different tissues. Similarity: Belongs to the prohibitin family. Database links: Entrez Gene: 5245 Human Entrez Gene: 18673 Mouse Omim: 176705 Human SwissProt: P35232 Human SwissProt: P67778 Mouse Unigene: 514303 Human Unigene: 263862 Mouse Unigene: 29754 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Prohibitin(phb)基因是一種有效的腫瘤抑制基因，廣泛分布于不同種屬的各種生物細(xì)胞中，它所編碼的產(chǎn)物Prohibitin(PHB)蛋白結(jié)構(gòu)保守，既存在于線粒體內(nèi)膜上，發(fā)揮分子伴侶作用，也存在于細(xì)胞核內(nèi)，具有負(fù)性轉(zhuǎn)錄調(diào)控作用，因而對(duì)細(xì)胞代謝、生長(zhǎng)、分化、衰老以及凋亡等諸多方面發(fā)揮 著重要的調(diào)控作用，可能與某些腫瘤和退行性疾病的發(fā)生有關(guān)。 |
