| 產(chǎn)品編號(hào) | bs-18889R |
| 英文名稱 | Rabbit Anti-NgR2/RTN4RL2 antibody |
| 中文名稱 | NOGO66受體相關(guān)蛋白2抗體 |
| 別 名 | NgR2; NGRH1; NGRL3; Nogo 66 receptor related protein 2; Nogo receptor-like 3; Nogo-66 receptor homolog 1; Nogo-66 receptor-related protein 2; R4RL2_HUMAN; Reticulon-4 receptor-like 2; RTN4RL2. |
| 研究領(lǐng)域 | 細(xì)胞生物 發(fā)育生物學(xué) 神經(jīng)生物學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 41kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NgR2/RTN4RL2: 81-180/420 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
NgR2 belongs to the Nogo receptor family and contains eight LRR (leucine-rich) repeats, one LRRNT domain and a single LRRCT domain. The gene encoding NgR2 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. Function: May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Subcellular Location: Cell membrane Tissue Specificity: Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. Post-translational modifications: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. Similarity: Belongs to the Nogo receptor family. Contains 8 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q86UN3 Gene ID: 349667 Database links: Entrez Gene: 349667 Human Entrez Gene: 269295 Mouse Omim: 610462 Human SwissProt: Q86UN3 Human SwissProt: Q7M6Z0 Mouse Unigene: 502618 Human Unigene: 389289 Mouse Unigene: 86447 Mouse Unigene: 162683 Rat |
