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Rabbit Anti-MTCBP1  antibody (bs-6507R)  
~~~促銷代碼KT202411~~~
訂購熱線:400-901-9800
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說明書: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價
產品編號 bs-6507R
英文名稱 Rabbit Anti-MTCBP1  antibody
中文名稱 膜型基質金屬蛋白酶胞質尾結合蛋白1抗體
別    名 ADI 1; Adi1; Adi-1; ADI1 antibody; APL1; ARD; EC 1.13.; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP 1; MTCBP-1; MTCBP1; MTND_HUMAN; Ni-ARD; SIPL; Submergence induced protein 2 homolog; Submergence-induced protein 2 homolog; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Aci reductone dioxygenase; Acireductone dioxygenase (Ni(2+)-requiring); Acireductone dioxygenase 1  
研究領域 腫瘤  信號轉導  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Chicken,Horse)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 23kDa
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTCBP1: 81-126/179 
亞    型
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 his gene encodes an enzyme that belongs to theaci-reductone dioxygenase family of metal-binding enzymes, whichare involved in methionine salvage. This enzyme may regulate mRNAprocessing in the nucleus, and may carry out different functionsdepending on its localization. Related pseudogenes have beendefined on chromosomes 8 and 20.

Function:
Catalyzes the formation of formate and2-keto-4-methylthiobutyrate (KMTB) from1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Alsodown-regulates cell migration mediated by MMP14. Necessary forhepatitis C virus replication in an otherwise non-permissive cellline.

Subunit:
Monomer (By similarity). Interacts with MMP14.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane;Peripheral membrane protein; Cytoplasmic side. Note=Localizes tothe plasma membrane when complexed to MMP14.

Tissue Specificity:
Detected in heart, colon, lung, stomach,brain, spleen, liver, skeletal muscle and kidney.

Similarity:
Belongs to the acireductone dioxygenase (ARD) family.

SWISS:
Q9BV57

Gene ID:
55256

Database links:

Entrez Gene: 55256 Human

Entrez Gene: 104923 Mouse

Entrez Gene: 298934 Rat

NCBI: NP_060739.2 Human

Omim: 613400 Human

SwissProt: Q9BV57 Human

SwissProt: Q99JT9 Mouse

SwissProt: Q562C9 Rat

Unigene: 502773 Human

Unigene: 291504 Mouse

Unigene: 12694 Rat



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