| 產(chǎn)品編號(hào) | bs-6518R |
| 英文名稱 | Rabbit Anti-CDK5RAP3 antibody |
| 中文名稱 | 周期素依賴性激酶5激活結(jié)合蛋白C53抗體 |
| 別 名 | C53; CDK5 activator binding protein C53; CDK5 regulatory subunit associated protein 3; HSF 27; HSF27; IC53; Ischemic heart CDK5 activator binding protein C53; LXXLL/leucine zipper containing ARFbinding protein; LZAP; MST016; OK/SW cl.114; PP1553; CK5P3_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 57kDa |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDK5RAP3: 51-150/506 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. Function: CDK5RAP3 may be involved in cell proliferation through regulation of the CDK5 family by interaction with CDK5 receptor 1. Subunit: Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3. Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1. Tissue Specificity: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. Post-translational modifications: Phosphorylated in vitro by CDK5 Similarity: Belongs to the CDK5RAP3 family. SWISS: Q96JB5 Gene ID: 80279 Database links: Entrez Gene: 80279 Human Entrez Gene: 80280 Mouse Omim: 608202 Human SwissProt: Q96JB5 Human SwissProt: Q99LM2 Mouse Unigene: 20157 Human Unigene: 28297 Mouse Unigene: 3727 Rat |
