| 產(chǎn)品編號 | bs-5892R |
| 英文名稱 | Rabbit Anti-ST14 antibody |
| 中文名稱 | 絲氨酸蛋白酶14/膜型絲氨酸蛋白酶1抗體 |
| 別 名 | Epithin; HAI; Matripase; Matriptase; Membrane type serine protease 1; Membrane type serine protease; Membrane-type serine protease 1; MT SP1; MT-SP1; MTSP 1; MTSP1; Prostamin; PRSS 14; PRSS14; Serine protease 14; Serine protease TADG 15; Serine protease TADG-15; Serine protease TADG15; SNC 19; SNC19; ST 14; ST14; ST14_HUMAN; Suppression of tumorigenicity 14 (colon carcinoma matriptase epithin); Suppression of tumorigenicity 14; Suppressor of tumorigenicity 14 protein; Suppressor of tumorigenicity protein 14; TADG 15; TADG15; TMPRSS14; Tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein. |
| 研究領(lǐng)域 | 腫瘤 細胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 激酶和磷酸酶 細胞骨架 細胞外基質(zhì) 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Rabbit) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 95kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ST14/MTSP1: 651-750/855 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
MTSP1 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. Function: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Subunit: Interacts with CDCP1. May interact with TMEFF1. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). DISEASE: Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair. Similarity: Belongs to the peptidase S1 family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains. Contains 1 peptidase S1 domain. SWISS: Q9Y5Y6 Gene ID: 6768 Database links: Entrez Gene: 6768 Human Entrez Gene: 19143 Mouse Omim: 606797 Human SwissProt: Q9Y5Y6 Human SwissProt: P56677 Mouse Unigene: 504315 Human Unigene: 243926 Mouse Unigene: 49170 Rat |
| 產(chǎn)品圖片 |
Sample:
Small intestine (Mouse) Lysate at 40 ug
Primary: Anti- ST14 (bs-5892R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 95 kD
Observed band size: 104 kD
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