| 產(chǎn)品編號 | bs-5850R |
| 英文名稱 | Rabbit Anti-ADAM19 antibody |
| 中文名稱 | 去整合素樣金屬蛋白酶19抗體 |
| 別 名 | A disintegrin and metalloproteinase domain 19 (meltrin beta); A disintegrin and metalloproteinase domain 19; ADAM 19; ADAM metallopeptidase domain 19; Disintegrin and metalloproteinase domain containing protein 19; FKSG 34; FKSG34; MADDAM; Meltrin beta; ADA19_HUMAN; Metalloprotease and disintegrin dentritic antigen marker; MLTN B; MLTNB. |
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Specific References (2) | bs-5850R has been referenced in 2 publications.
[IF=1.655] Moe Endo et al. Increased soluble (pro) renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells
. 2020 Jul;25(7):483-497. ICC,WB ; human.
[IF=1.655] Endo M et al. Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells. 2020 Jul;25(7):483-497. WB&ICC ; Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞骨架 細(xì)胞外基質(zhì) 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Pig) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 82kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADAM19: 251-350/955 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]. Function: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). Subunit: Interacts with SH3PXD2A. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in many normal organ tissues and several cancer cell lines. Post-translational modifications: The precursor is cleaved by a furin endopeptidase (By similarity). Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. SWISS: Q9H013 Gene ID: 8728 Database links: Entrez Gene: 8728 Human Entrez Gene: 11492 Mouse Omim: 603640 Human SwissProt: Q9H013 Human SwissProt: O35674 Mouse SwissProt: Q14BL7 Mouse SwissProt: Q80UF6 Mouse Unigene: 89940 Mouse 細(xì)胞外基質(zhì)蛋白 |
| 產(chǎn)品圖片 |
Sample:
U251(Human) Cell Lysate at 30 ug
Primary: Anti- ADAM19 (bs-5850R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 82 kD
Observed band size: 82 kD
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