| 產(chǎn)品編號 | bs-2682R |
| 英文名稱 | Rabbit Anti-SLAMF6/LY108 antibody |
| 中文名稱 | SLAMF6抗體 |
| 別 名 | LY108; Activating NK receptor; KALI; KALIb; MGC104953; NK T B antigen; NTB A; NTBA; SF2000; SLAM family member 6; SLAM family member 6 precursor; SLAMF6; SLAF6_HUMAN; NK-T-B-antigen; NTB-A; CD352. |
| 研究領(lǐng)域 | 免疫學(xué) 細(xì)胞表面分子 細(xì)胞類型標(biāo)志物 自然殺傷細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 37kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse SLAMF6: 51-150/331 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. It may play a role in the regulation of autoimmune diseases. Function: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Subunit: Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Subcellular Location: Cell membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. Similarity: Contains 1 Ig-like (immunoglobulin-like) domain. SWISS: Q9ET39 Gene ID: 30925 Database links: Entrez Gene: 114836 Human Entrez Gene: 30925 Mouse Omim: 606446 Human SwissProt: Q96DU3 Human SwissProt: Q9ET39 Mouse Unigene: 492348 Human Unigene: 486404 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lymph node (Mouse) Lysate at 40 ug
Primary: Anti-LY108 (bs-2682R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 37 kD
Observed band size: 48 kD
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