| 產(chǎn)品編號 | bs-2632R |
| 英文名稱 | Rabbit Anti-IL32 antibody |
| 中文名稱 | 白介素32抗體 |
| 別 名 | Interleukin-32/Natural killer cells protein 4; IL32; IL-32; IL 32; IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; natural killer transcript 4; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; tumor necrosis factor alpha-inducing factor alpha; IL32_HUMAN. |
| 研究領(lǐng)域 | 心血管 免疫學(xué) 激酶和磷酸酶 細(xì)胞表面分子 自然殺傷細(xì)胞 t-淋巴細(xì)胞 上皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-32: 151-234/234 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Interleukin 32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. As treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-alpha, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN-gamma, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis. Function: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. Subcellular Location: Secreted. Tissue Specificity: Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells. SWISS: P24001 Gene ID: 9235 Database links: Entrez Gene: 9235 Human Omim: 606001 Human SwissProt: P24001 Human Unigene: 943 Human IL-32是近年來發(fā)現(xiàn)的一種炎性細(xì)胞因子，主要由T淋巴細(xì)胞、NK細(xì)胞、單核細(xì)胞和上皮細(xì)胞等產(chǎn)生。IL-32誘導(dǎo)細(xì)胞因子的產(chǎn)生，在自身免疫方面起重要作用。< |
